Preface
Brian L. Erstad, Pharm.D., FCCP, BCPS
Foreword
Joseph F. Dasta, M.S., FCCP; Curtis N. Sessler, M.D., FCCP, FCCM;
Ashlee Dauenhauer, Pharm.D.;and Ohoud A. Aljuhani, Pharm.D.
Letter from ACCP
Judith Jacobi, FCCP, MCCM, BCPS, BCCCP, ACCP President 2014–
2015
SECTION 1: SUPPORTIVE CARE
Chapter 1: Acid-Base Disorders
Curtis E. Haas, Pharm.D.; David C. Kaufman, M.D.; and Brian L.
Erstad, Pharm.D., FCCP, BCPS
Chapter 2: Fluid Therapy in the Critically Ill Patient
Brian L. Erstad, Pharm.D., FCCP, BCPS
Chapter 3: Electrolyte Disorders in the Critically Ill Population
Jeffrey J. Bruno, Pharm.D., BCPS, BCNSP; and Todd W. Canada,
Pharm.D., FASHP, FTSHP, BCNSP
Chapter 4: Nutrition Support Therapy in Critically Ill Patients
Amber Verdell, Pharm.D., BCPS, BCNSP; and Carol J. Rollins, M.S.,
RD, Pharm.D., FASHP,FASPEN, BCNSP
Chapter 5: Glucose Management in the Critically Ill Population
Paul M. Szumita, Pharm.D., FCCM, BCCCP, BCPS; and James F.
Gilmore, Pharm.D., BCCCP, BCPS
Chapter 6: Analgesia
Asad E. Patanwala, Pharm.D.
Chapter 7: Agitation and Comfort in the Intensive Care Unit
David J. Gagnon, Pharm.D.; Nicole Kovacic, Pharm.D.; and Gilles L.
Fraser, Pharm.D., MCCM
Chapter 8: Delirium in Critically Ill Adults
John W. Devlin, Pharm.D., FCCP, FCCM
Chapter 9: Neuromuscular Blocking Agents
M. Claire McManus, Pharm.D., BS(Pharm)
Chapter 10: Shock Syndromes
Ishaq Lat, Pharm.D., FCCP, FCCM, BCPS; and Sajni Patel, Pharm.D.,
BCPS
SECTION 2: INFECTIOUS DISEASES
Chapter 11: Appropriate Use of Antimicrobials
Scott T. Micek, Pharm.D.; and Marin H. Kollef, M.D.
Chapter 12: Pharmacokinetic and Pharmacodynamic Considerations
for Antimicrobial Use in Critically Ill Patients
Douglas N. Fish, Pharm.D., FCCP, FCCM, BCPS-AQ ID
Chapter 13: Laboratory Testing Considerations
Kali Martin, Pharm.D.; Shanna Cole, Pharm.D.; and Michael Klepser,
Pharm.D.
Chapter 14: Antimicrobial Resistance in the Critical Care Environment
Andrew M. Roecker, Pharm.D.; and Steven J. Martin, Pharm.D.
Chapter 15: Severe Sepsis and Septic Shock
Seth R. Bauer, Pharm.D., FCCM, BCPS; Simon W. Lam, Pharm.D.,
FCCM, BCPS; and Lance J. Oyen, Pharm.D., FCCM, FCCP, BCPS
Chapter 16: Invasive Fungal Infections
Kathryn R. Matthias, Pharm.D., BCPS-AQ ID
Chapter 17: Invasive Viral Infections in the Intensive Care Unit
P. Brandon Bookstaver, Pharm.D., FCCP, BCPS-AQ ID, AAHIVP; and
Caroline B. Derrick,Pharm.D., BCPS
Chapter 18: Antimicrobial Prophylaxis
Keith M. Olsen, Pharm.D., FCCP, FCCM; and Gregory Peitz,
Pharm.D., BCPS
SECTION 3: NEUROCRITICAL CARE
Chapter 19: Status Epilepticus and Acute Seizure Management
Eljim P. Tesoro, Pharm.D., BCPS; Karen Berger, Pharm.D., BCPS; and
Gretchen M. Brophy,Pharm.D., FCCP, FCCM, FNCS, BCPS
Chapter 20: Traumatic Brain Injury and Acute Spinal Cord Injury
A. Shaun Rowe, Pharm.D., BCPS; and Bradley A. Boucher, Pharm.D.,
BCPS
Chapter 21: Acute Management of Stroke
Martina Holder, Pharm.D., BCPS; and Stacy Voils, Pharm.D., M.Sc.,
BCPS
Chapter 22: Critical Care Management of Aneurysmal Subarachnoid
Hemorrhage
Denise H. Rhoney, Pharm.D., FCCP, FCCM, FNCS; Kathryn Morbitzer,
Pharm.D.; and J. Dedrick Jordan, M.D., Ph.D.
SECTION 4: HEMATOLOGY
Chapter 23: Prevention and Treatment of Venous Thromboembolism
William E. Dager, Pharm.D., FCCP, FCCM, FCSHP, FASHP, MCCM,
BCPS; and A. Josh Roberts, Pharm.D., BCPS
Chapter 24: Hemostatic Agents for the Prevention and Management of
Hemorrhage in the ICU
Robert MacLaren, Pharm.D., MPH, FCCP, FCCM; Bradley A. Boucher,
Pharm.D.,FCCP, FCCM; and Laura Baumgartner, Pharm.D.
Chapter 25: Laboratory Testing with Anticoagulation
Tyree H. Kiser, Pharm.D., FCCP, FCCM, BCPS
SECTION 5: ACUTE KIDNEY INJURY
Chapter 26: Acute Kidney Injury—Prevention and Management
Curtis L. Smith, Pharm.D., BCPS; and Thomas C. Dowling, Pharm.D.,
Ph.D., FCCP, FCP
Chapter 27: Drug Dosing in Acute Kidney Injury and Extracorporeal
Therapies
Melanie S. Joy, Pharm.D., Ph.D., FCCP, FASN; Michael L. Bentley,
Pharm.D.; and Katja M. Gist, D.O., M.A., MSCS
SECTION 6: Liver/GASTROINTESTINAL
Chapter 28: Management and Drug Dosing in Acute Liver Failure
Andrew C. Fritschle Hilliard, Pharm.D., BCPS, BCCCP; and David R.
Foster, Pharm.D., FCCP
Chapter 29: Acute Gastrointestinal Bleeding: Prophylaxis and
Treatment
Salmaan Kanji, Bsc. Pharm, Pharm.D.; and David Williamson, B.
Pharm, M.Sc., Ph.D., BCPS
SECTION 7: ACUTE PULMONARY DISEASE
Chapter 30: Pulmonary Arterial Hypertension
Steven E. Pass, Pharm.D., FCCP, FCCM, FASHP, BCPS; and Joseph
E. Mazur, Pharm.D., BCPS
Chapter 31: Critical Care Management of Asthma and Chronic
Obstructive Pulmonary Disease
Amanda Zomp, Pharm.D., BCPS; Katherine Bidwell, Pharm.D., BCPS;
and Stephanie Mallow Corbett, Pharm.D., FCCM
SECTION 8: CARDIOVASCULAR CRITICAL CARE
Chapter 32: Acute Decompensated Heart Failure
Jo E. Rodgers, Pharm.D., FCCP, BCPS-AQ Cardiology; and Brent N.
Reed, Pharm.D.,FAHA, BCPS-AQ Cardiology
Chapter 33: Management of Acute Coronary Syndrome
Zachary A. Stacy, Pharm.D., M.S., FCCP, BCPS; and Paul P. Dobesh,
Pharm.D., FCCP,BCPS-AQ Cardiology
Chapter 34: Management of Cardiac Arrest
Toby C. Trujillo, Pharm.D., FCCP, FAHA, BCPS-AQ Cardiology
Chapter 35: Acute Management of Arrhythmias
James E. Tisdale, Pharm.D., FCCP, FAPhA, FAHA, BCPS
Chapter 36: Pharmacologic Challenges During Mechanical Circulatory
Support in Adults
Amy L. Dzierba, Pharm.D., FCCM, BCPS; and Erik Abel, Pharm.D.,
BCPS
SECTION 9: OTHER URGENCIES AND EMERGENCIES
Chapter 37: Hypertensive Crisis
Jeremy Flynn, Pharm.D., FCCP, FCCM; Melissa Nestor, Pharm.D.,
BCPS; and Komal Pandya,Pharm.D., BCPS
Chapter 38: Medication Withdrawal in the Intensive Care Unit
Colgan T. Sloan, Pharm.D., BCPS; Robert French, M.D., MPH;
Nicholas B. Hurst, M.D., M.S.;Stephen R. Karpen, Pharm.D.; and
Mazda Shirazi, M.D., Ph.D.
Chapter 39: Endocrine Disorders
Robert L. Talbert, Pharm.D.
Chapter 40: Oncologic Emergencies
Ali McBride, Pharm.D., M.S., BCPS, BCOP; Michelle Nadeau,
Pharm.D., BCPS; and Cory M. Vela, Pharm.D.
SECTION 10: MISCELLANEOUS
Chapter 41: Drug Dosing in Special Intensive Care Unit Populations
Jeffrey F. Barletta, Pharm.D., FCCM
Chapter 42: Management of the Critically Ill Burn Patient
Claire V. Murphy, Pharm.D., BCPS; and Kate Oltrogge Pape,
Pharm.D., BCPS
Chapter 43: The Role of Pharmacotherapy in the Treatment of the
Multiple Trauma Patient
Rita Gayed, Pharm.D.; Prasad Abraham, Pharm.D., FCCM, BCPS;
and David V. Feliciano,M.D., FACS
Chapter 44: Pediatric Critical Care
Elizabeth Farrington, Pharm.D., FCCP, FCCM, FPPAG, BCPS
Chapter 45: Drug Shortages: An Overview of Causes, Impact, and
Management Strategies
Samuel E. Culli, Pharm.D., MPH; and John J. Lewin III, Pharm.D.,
MBA, FASHP,FCCM, FNCS
Chapter 46: Drug Interactions in the Intensive Care Unit
Cristian Merchan, Pharm.D.; and John Papadopoulos, Pharm.D., B.S.,
FCCM, BCNSP
Chapter 47: Acute Illness Scoring Systems
Thomas J. Johnson, Pharm.D., MBA, FASHP, FCCM, BCPS
Chapter 48: Leading and Managing Intensive Care Unit Pharmacy
Services
Robert J. Weber, Pharm.D., M.S., FASHP, BCPS
Chapter 49: Medication Safety and Active Surveillance
Sandra L. Kane-Gill, Pharm.D., M.Sc., FCCP, FCCM; and Mitchell S.
Buckley, Pharm.D.,FCCP, FASHP, FCCM, BCPS
Chapter 50: Care of the Immunocompromised Patient
Heather Personett, Pharm.D., BCPS; and Simon W. Lam, Pharm.D.,
FCCM, BCPS
Chapter 51: Clinically Applied Pharmacogenomics in Critical Care
Settings
Samuel G. Johnson, Pharm.D., FCCP; and Christina L. Aquilante,
Pharm.D., FCCP
Contributors
Reviewers
Index
Disclosure of Potential Conflicts of Interest