Contributors
Conflicts of Interest
Preface
Important Notice (Please Read)
1. Introduction / 1
DOUGLAS D. RICHMAN, RICHARD J. WHITLEY,
AND FREDERICK G. HAYDEN
Section I
Viral Syndromes and
General Principles
2. Respiratory Infections / 9
JOHN J. TREANOR
3. Viral Infections of the Central Nervous
System / 31
KEVIN A. CASSADY AND RICHARD J. WHITLEY
4. Gastrointestinal Syndromes / 47
EYAL LESHEM AND UMESH D. PARASHAR
5. Viral Hepatitis / 61
ZINA S. VALAYDON, STEPHEN A. LOCARNINI,
AND ALEXANDER J.V. THOMPSON
6. Viral Infections in Organ Transplant
Recipients / 75
JOHN A. ZAIA
7. Viral Heart Disease / 99
BRUCE M. McMANUS, MICHAEL SEIDMAN,
KARIN KLINGEL, AND HONGLIN LUO
8. Viral Diseases of the Skin / 115
ZEENAY. NAWAS AND STEPHEN K. TYRING
9. Viral Hemorrhagic Fevers / 141
GAIL CARSON, MIKE BRAY, AND CATHY ROTH
10. Viral Disease of the Eye / 151
HOWARD M. NEWMAN
11. Antiretroviral Agents / 169
CHRISTINE J. KUBIN, BARBARA S. TAYLOR,
AND SCOTT M. HAMMER
12. Antiherpesvirus Agents / 215
CLAIRE L. GORDON, CHRISTINE J. KUBIN,
AND SCOTT M. HAMMER
13. Anti–Hepatitis Virus Agents / 239
MATTHEW L. SCHERER, CHELSEA SAMMONS,
BRIAN NELSON, SCOTT M. HAMMER,
AND ELIZABETH VERNA
14. Antirespiratory Virus Agents / 271
MARCUS R. PEREIRA, BENJAMIN A. MIKO,
MONICA MEHTA, AND SCOTT M. HAMMER
15. Diagnosis of Viral Infections / 291
GUY BOIVIN, TONY MAZZULLI,
AND MARTIN PETRIC
16. Immune Responses to Viral Infection / 321
HENDRIK STREECK, TODD J. SUSCOVICH,
AND GALIT ALTER
17. Immunization Against Viral Diseases / 351
JULIE E. LEDGERWOOD
AND BARNEY S. GRAHAM
18. Chronic Fatigue and Postinfective Fatigue
Syndromes / 371
ANDREW R. LLOYD
Section II
The Agents
Part A: DNA Viruses
19. Poxviruses / 387
STUART N. ISAACS AND R. MARK BULLER
20. Herpes Simplex Viruses / 415
RICHARD J. WHITLEY AND BERNARD ROIZMAN
21. Cercopithecine Herpesvirus 1 (B Virus) / 447
RICHARD J. WHITLEY
vii
22. Varicella-Zoster Virus / 459
ANNE A. GERSHON AND MICHAEL D. GERSHON
23. Cytomegalovirus / 481
PAUL DAVID GRIFFITHS AND MATTHEW REEVES
24. Human Herpesvirus 6 and Human
Herpesvirus 7 / 511
KOICHI YAMANISHI AND YASUKO MORI
25. Epstein-Barr Virus / 523
JOYCE FINGEROTH
26. Kaposi’s Sarcoma-Associated Herpesvirus
(KSHV/HHV8) / 549
YUAN CHANG, SHOU-JIANG GAO,
AND PATRICK S. MOORE
27. Adenoviruses / 575
OLLI RUUSKANEN, JORDAN P. METCALF,
MATTI WARIS, AND GÖRAN AKUSJÄRVI
28. Polyomaviruses / 599
JOHN E. GREENLEE AND HANS H. HIRSCH
29. Papillomavirus / 625
WILLIAM BONNEZ
30. Human Parvoviruses / 679
MARIA SÖDERLUND-VENERMO,
KEVIN E. BROWN, AND DEAN D. ERDMAN
31. Anelloviridae / 701
PETER SIMMONDS AND COLIN P. SHARP
32. Hepatitis B Virus / 713
DARREN J. WONG, STEPHEN A. LOCARNINI,
AND ALEXANDER J.V. THOMPSON
Part B: RNA Viruses
33. Human Lymphotropic Viruses: HTLV-1
and HTLV-2 / 771
ROBERTA L. BRUHN, RENAUD MAHIEUX,
AND EDWARD L. MURPHY
34. Human Immunodeficiency Virus / 795
JOHN C. GUATELLI, ROBERT F. SILICIANO,
DANIEL R. KURITZKES, AND
DOUGLAS D. RICHMAN
35. Colorado Tick Fever and Other Arthropod
Borne Reoviridae / 841
STEVEN YUKL AND JOSEPH K. WONG
36. Rotaviruses / 853
MANUEL A. FRANCO, JUANA ANGEL,
AND HARRY B. GREENBERG
37. Respiratory Syncytial Virus, Human
Metapneumovirus, and Parainfluenza
Viruses / 873
JOHN V. WILLIAMS, PEDRO A. PIEDRA,
AND JANET A. ENGLUND
38. Measles / 903
WILLIAM J. MOSS AND DIANE E. GRIFFIN
39. Mumps Virus / 929
JOHN W. GNANN, JR. AND DONALD R. LATNER
40. Zoonotic Paramyxoviruses / 949
DANIELLE E. ANDERSON AND LIN-FAWANG
41. Rhabdoviruses / 967
ALAN C. JACKSON
42. Filoviruses / 981
MIKE BRAY AND DANIEL S. CHERTOW
43. Influenza Virus / 1009
FREDERICK G. HAYDEN AND PETER PALESE
44. Bunyaviridae: Orthobunyaviruses,
Phleboviruses, Nairoviruses,
and Hantaviruses / 1059
GREGORY J. MERTZ, CLAS AHLM,
AND COLLEEN B. JONSSON
45. Arenaviruses / 1089
DANIEL G. BAUSCH
46. Enteroviruses / 1113
JOSÉ R. ROMERO
47. Rhinovirus / 1143
WAI-MING LEE AND JAMES E. GERN
48. Hepatitis A Virus / 1165
SARA E. WILLIFORD AND STANLEY M. LEMON
49. Human Caliciviruses / 1189
ROBERT L. ATMAR AND MARY K. ESTES
50. Hepatitis E Virus / 1209
HARRY R. DALTON, NASSIM KAMAR,
AND JACQUES IZOPET
51. Astrovirus / 1231
CARLOS F. ARIAS AND TOMÁS LÓPEZ
52. Coronaviruses / 1243
J.S.M. PEIRIS
53. Arthropod-Borne Flaviviruses / 1267
LYLE R. PETERSEN AND ALAN D.T. BARRETT
54. Hepatitis C Virus / 1313
CHRISTOPHER KOH, QISHENG LI,
AND JAKE LIANG
55. Alphaviruses / 1347
DAVID W. SMITH, JOHN S. MACKENZIE,
ILYAV. FROLOV, AND SCOTT C. WEAVER
56. Rubella Virus / 1381
DAVID W. KIMBERLIN
57. Infections Caused by Bornaviruses / 1395
RALF DÜRRWALD, NORBERT NOWOTNY,
MARTIN BEER, AND JENS H. KUHN
Part C: Subviral Agents
58. Hepatitis D / 1409
MARIO RIZZETTO, ANTONINA SMEDILE,
AND ALESSIA CIANCIO
59. Prion Diseases / 1425
CHRISTINA J. SIGURDSON, MEE-OHK KIM,
AND MICHAEL D. GESCHWIND
Subject Index / 1449
viii - CONTENTS

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